After first discovery, the most prominent application of anti-Müllerian hormone ( AMH) was used in determining fetal gender in cases when fetal genitalia was ambiguous.  Today, AMH has a much wider range of testing and diagnostic applications and is more often used to estimate ovarian reserves in women, to predict menopause, and to detect polycystic ovary syndrome (PCOS) and ovarian failure.  To test the function of a fetus or a woman’s reproductive system, Ansh Labs offers reliable immunoassay test kits that make testing for anti-Müllerian hormone (AMH) and other TGF-beta superfamily hormones used in folliculogenesis simple. 

Ansh Labs’ reliable assays are frequently used in many ongoing studies of such hormones, and the future is brighter than ever for new diagnostic applications in gynecology and oncology in part because of the collaboration of research and testing are done by us.  Ansh Labs is the leader in AMH studies and test kits, and our products are trustworthy and effective every time. 

More About AMH

In mammals, AMH blocks the growth of the Müllerian ducts into the uterus.  In human beings, this process occurs within the first two months of the gestation phase.  During this time, if hormones aren’t being produced from the gonads of the fetus, the Müllerian ducts will develop automatically, but the Wolffian ducts (which cause male reproductive parts to grow) will naturally die.  Our assays allow testing for accurate information.

AMH is a product of the granulosa cells, which cover the woman’s every egg and give them energy.  AMH also serves as a biomarker for measuring the relative size of a woman’s ovarian reserve.  This biomarker is essential for predicting timing the onset of menopause.  AMH is also used as a biomarker to detect ovarian dysfunction, such as in women with polycystic ovary syndrome (PCOS) and ovarian failure.  However, it’s not only women who are affected by AMH levels. 

Lack of sufficient embryonal AMH presence can lead to Persistent Müllerian duct syndrome (PMDS) in men.  PMDS is uncommon, but when it occurs, it causes a rudimentary uterus to grow in the male and prevents the male’s testes from descending.  AMH measurements are now regularly implemented in the assessment of testicular presence and functions in babies with intersex conditions, ambiguous genitalia, and cryptorchidism.

Anti-Müllerian hormone is also known as the Müllerian-inhibiting hormone (MIH) and is glycoprotein hormone that plays a crucial role in folliculogenesis.  As mentioned, AMH is critical to gender differentiation throughout fetal development.  SOX9 activates AMH within the Sertoli cells of male fetuses, and it’s presence blocks the growth of female sex organs.  Abnormalities in AMH levels can lead to gender confusion.

The granulosa cells of the ovary express AMH during a woman’s reproductive years.  AMH limits the primary formation of follicles by blocking the recruitment by FSH.  AMH is most prevalent during the recruitment phase of folliculogenesis in the preantral and small antral follicles. Once these follicles grow and enter the selection stage, AMH diminishes and FSH increases.  

AMH can be found in the ovaries of a woman until the time she reaches menopause.  AMH is produced in women to control folliculogenesis by stopping the recruitment of follicles from the resting pool to find the dominant follicle.  After this occurs, the presence of AMH dissipates.  If you need to be tested for AMH, contact Ansh Labs today.

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